Transplant Proc. 2026 Feb 6:S0041-1345(26)00033-3. doi: 10.1016/j.transproceed.2025.11.015. Online ahead of print.
ABSTRACT
While renal transplantation significantly enhances both life expectancy and quality of life in patients with end-stage renal disease, the necessity for lifelong immunosuppressive therapy, aimed at prolonging graft survival and maintaining optimal function, comes with certain disadvantages, including an increased risk of developing related complications such as infections, cardiovascular disease, or various types of cancer. Given the limited availability of renal grafts, urologists often endeavor to preserve these precious resources whenever possible. This report examines a 62-year-old woman with a kidney transplant who developed recurrent renal carcinoma, first identified 13 years after the transplant and recurring 3 years later, necessitating 2 partial nephrectomies on the graft. This case report underscores the crucial importance of early diagnosis in renal allograft malignancy and highlights the favorable outcomes achievable through partial nephrectomy, even in recurrent tumors. This is the first report of recurrent RCC in a renal allograft successfully treated with 2 consecutive nephron-sparing surgeries (NSS).
PMID:41654431 | DOI:10.1016/j.transproceed.2025.11.015