Health Sci Rep. 2026 Jul 25;9(8):e72841. doi: 10.1002/hsr2.72841. eCollection 2026 Aug.
ABSTRACT
BACKGROUND AND AIMS: Recent advancements in gene expression studies have shed light on the role of non-coding RNAs in negatively regulating mRNA and inhibiting mRNA translation. Given the significant impact of miRNAs on cardiovascular function, our review aims to comprehensively explore their contribution to mitigating heart injury and their protective effects during cardioplegic-induced cardiac arrest.
METHODS: A systematic search conducted in December 2023 across PubMed, Web of Science, Scopus, and Google Scholar yielded valuable insights.
RESULTS: Our findings indicate that cardioplegia leads to the upregulation of several miRNAs, including miR-208b, miR-499-5p, miR-10b, miR-96, miR-339-5p, and miR-483-3p, alongside the downregulation of miR-139-5p, and miR-194-5p. Many of these miRNAs are implicated in cardiac pathophysiology, particularly in myocardial injury following cardioplegia in on-pump cardiac surgery.
CONCLUSION: While current applications of discovered miRNAs primarily focus on early diagnosis and prognosis of cardiac conditions, their therapeutic potential holds promise for revolutionizing the management of various heart diseases in the future. By elucidating the intricate roles of miRNAs in cardiac health and disease, this review underscores the importance of harnessing their therapeutic potential for improved patient outcomes.
PMID:42504224 | PMC:PMC13401706 | DOI:10.1002/hsr2.72841