An Acad Bras Cienc. 2025 Dec 5;97(suppl 4):e20250045. doi: 10.1590/0001-3765202520250045. eCollection 2025.
ABSTRACT
A maternal diet high in saturated fat during critical periods of development is associated with an increased risk of chronic diseases in adulthood. We investigated whether cardiovascular effects in adulthood can be altered by the maternal high-fat diet with flaxseed oil (omega-3) as well as the effects of this diet in dams. Wistar rats were fed during pregnancy and lactation according to the following: control (CT) - standard diet; high-fat (HL) - diet rich in saturated fatty acids; and high-fat with omega-3 (HLꞶ3) - diet rich in omega-3 from flaxseed oil. Body mass, lipid peroxidation, biochemical profile, heart and kidney weights and cardiac hypertrophy index (CHI) were measured in dams. In the offspring, body mass, murine parameters, dietary and water control, systolic and diastolic blood pressure at 60 and 90 days, biochemical parameters, heart and kidney weights, CHI and vascular reactivity were evaluated. In dams, the HLꞶ3 diet delayed the increase in body mass in lactation and reversed oxidative damage in the heart. Therefore, our data suggest that HL diet promotes adverse cardiometabolic effects and the HLꞶ3 diet attenuated the weight gain and oxidative stress in dams, while in the offspring the HLꞶ3 prevented the increase in the Phe-induced contraction.
PMID:41370444 | DOI:10.1590/0001-3765202520250045