Ann Surg Oncol. 2026 Mar 5. doi: 10.1245/s10434-026-19386-7. Online ahead of print.
ABSTRACT
OBJECTIVE: This study aimed to investigate the incidence, characteristics, risk factors, and prognostic implications of myocardial injury after non-cardiac surgery (MINS) in patients with lung cancer undergoing pulmonary resection.
MATERIALS AND METHODS: We conducted a retrospective analysis of 1314 consecutive patients with lung cancer undergoing elective pulmonary resection between June and November 2023 at a tertiary cancer referral center. Univariate and multivariate logistic regression analyses were used to identify independent risk factors. Kaplan-Meier survival analysis with log-rank tests were adopted to evaluate the 30 day mortality and major adverse cardiovascular events (MACE). Subgroup analyses according to the extent of lung resection were also conducted.
RESULTS: The overall incidence of MINS following lung cancer surgery was 10.4%. The majority of cases (92.7%) occurred within the first postoperative day and demonstrated predominantly asymptomatic presentation (78.1%). Independent preoperative risk factors for MINS included male sex, coronary artery disease, creatinine, high-sensitivity cardiac troponin T, thoracotomy, lobectomy, and duration of tachycardia. Although MINS showed no association with 30 day postoperative mortality, it significantly increased the risk of MACE at 30 days in the overall (7.3% vs. 0.2%, p < 0.001), lobectomy (7.0% vs. 0.3%, p < 0.001), and sublobar resection (9.1% vs. 0, p = 0.002) cohorts.
CONCLUSIONS: MINS is a common postoperative complication following lung cancer surgery, and typically occurs in the early postoperative period. Although it is predominantly asymptomatic, it was significantly associated with increased 30 day MACE.
PMID:41784722 | DOI:10.1245/s10434-026-19386-7