J Clin Lipidol. 2026 Jan;20(1S):21-25. doi: 10.1016/j.jacl.2025.06.016.
ABSTRACT
BACKGROUND: Obesity is an increasingly common, multifactorial condition with significant consequences for patients and the healthcare system. Obesity represents a major modifiable risk factor for cardiovascular disease, type 2 diabetes and metabolic syndrome. Understanding of the pathways and mechanisms involved in the development of obesity will allow for further advancement in treatment modalities.
SOURCES OF MATERIAL: Evidence was drawn from current peer-reviewed literature addressing the pathophysiology of obesity identified via PubMed searches.
ABSTRACT OF FINDINGS: Obesity results from impaired energy homeostasis and chronic positive energy balance. The etiology of the positive energy balance is often a complex interplay of genetic, environmental, neurohormonal, and psychosocial factors. This paper discusses the pathophysiology of obesity. Topics included in this discussion are the genetics of obesity, the process of energy regulation and metabolism of adipose tissue. Also discussed is how visceral obesity is especially harmful, as it promotes insulin resistance, altered lipid metabolism, and inflammation.
CONCLUSION: Understanding the underlying pathophysiology of obesity is crucial for making advances in treating this condition with a more individualized approach.
PMID:41708211 | DOI:10.1016/j.jacl.2025.06.016