Open Life Sci. 2026 Aug 24;21(1):20251366. doi: 10.1515/biol-2025-1366. eCollection 2026 Jan.
ABSTRACT
A major focus of contemporary medical research is the primary pathological cardiovascular diseases, whereas stress-induced vascular senescence is a process with degenerative changes in vascular morphology, structure, and function caused by oxidative stress (OS), inflammation, autophagy disorders, and other factors. Silent information regulator of transcription 1 (SIRT1), which may be a key gene linking oxidative stress and aging, has extensive biological functions in anti-oxidation, anti-inflammation, anti-apoptosis, and other aspects. This paper focuses on the protective effects and main mechanisms of SIRT1 on stress-induced vascular senescence and provides clues for preventing and treating diseases related to stress-induced vascular senescence.
PMID:42633089 | PMC:PMC13499030 | DOI:10.1515/biol-2025-1366