Nat Commun. 2026 Apr 27. doi: 10.1038/s41467-026-71822-0. Online ahead of print.
ABSTRACT
Cdr1as/ciRS-7 is a circular RNA conserved in mammals and highly expressed in brain. It features a large number of microRNA target sites bound in vivo by miR-7/miR-671. Cdr1as regulates synaptic activity under stress in a temporal, spatial, and neuron-specific manner. We review genetic, molecular, evolutionary, and physiological data to discuss how Cdr1as and its interactors form a functionally important network of non-coding RNAs that regulates neuronal adaptability. We provide a framework to explore potential roles of other non-coding RNA networks on brain function and their diagnostic and therapeutic potential.
PMID:42045181 | DOI:10.1038/s41467-026-71822-0