J Clin Lipidol. 2026 Jun 22:S1933-2874(26)00405-8. doi: 10.1016/j.jacl.2026.06.015. Online ahead of print.
ABSTRACT
BACKGROUND: Familial hypercholesterolemia (FH) confers lifelong elevation in low-density lipoprotein-cholesterol (LDL-C) and markedly increases the risk for premature atherosclerotic cardiovascular disease. Because atherosclerosis begins early in FH, timely initiation of statin therapy reduces lifetime LDL-C exposure, slows disease progression, and improves cardiovascular event-free survival.
SOURCES OF MATERIAL: Relevant studies were identified through PubMed and Embase searches (2010-2025) using the terms FH, transition of care, and lipid management, supplemented by guidelines and consensus statements from the American Heart Association, American College of Cardiology, and National Lipid Association. ABSTRACT OF FINDINGS: Evidence highlights a persistent gap in lipid care as adolescents with FH transition to adult systems. Emerging adulthood represents a vulnerable period often associated with lapses in adherence and loss of continuity in lipid care. Few studies address FH transition directly; however, structured transition programs in other chronic conditions demonstrate improved adherence, self-management, and long-term outcomes. Adaptation of the Six Core Elements of Health Care Transition framework provides a structured, multidisciplinary model to guide the planned transfer of patients from pediatric to adult care.
CONCLUSION: Adaptation of the Six Core Elements of Health Care Transition framework provides a structured, multidisciplinary model to guide adult lipidologists in the acceptance and integration of patients transferring from pediatric to adult care. This approach may bridge care gaps, enhance treatment continuity, and promote sustained cardiovascular prevention across the lifespan.
PMID:42463370 | DOI:10.1016/j.jacl.2026.06.015