Ferroptosis-Associated Fibroblast Activation and Transcriptional Remodelling in Human Heart Failure: A Proof-of-Concept Study

Scritto il 12/05/2026
da Konstantinos I Karampinos

Eur J Clin Invest. 2026 May;56(5):e70213. doi: 10.1111/eci.70213.

ABSTRACT

Single-cell analysis of human heart failure identifies a fibroblast-enriched ferroptosis signature that distinguishes DCM from controls and reveals a pseudotime trajectory linking ferroptotic stress to progressive fibroblast activation and pro-fibrotic remodelling.

PMID:42118227 | DOI:10.1111/eci.70213