J Stroke Cerebrovasc Dis. 2026 Apr 8:108633. doi: 10.1016/j.jstrokecerebrovasdis.2026.108633. Online ahead of print.
ABSTRACT
BACKGROUND AND AIMS: White matter hyperintensities (WMH) of presumed vascular origin are reliable neuroimaging markers of cerebral small vessel disease (cSVD). However, their underlying systemic correlates remain incompletely understood. Nailfold capillaroscopy (NFC) provides direct visualization of peripheral microvascular health, and megacapillaries represent a reproducible indicator of severe endothelial injury. Whether such peripheral microvascular abnormalities mirror structural brain changes in sporadic cSVD is unknown. We investigated the association between megacapillaries and WMH severity in a population-based cohort.
METHODS: Community-dwelling older adults from the Atahualpa Project underwent NFC and brain MRI. Individuals with autoimmune, hereditary, or demyelinating disorders were excluded. Megacapillaries were defined as capillary loops >50 μm in diameter. WMH were graded using the modified Fazekas scale and dichotomized as none-to-mild versus moderate-to-severe, reflecting meaningful burden. Logistic regression models adjusted for demographics and cardiovascular risk factors, assessed the association between megacapillaries and WMH burden.
RESULTS: Among 289 eligible participants (mean age 71.3±7.5 years; 51% women), megacapillaries were identified in 15 (5%) and moderate-to-severe WMH in 96 (33%). Megacapillaries were more frequent in individuals with moderate-to-severe WMH. In adjusted models, megacapillaries were independently associated with moderate-to-severe WMH (OR: 4.49; 95% C.I.: 1.35-14.96), along with older age, lower educational attainment, and hypertension.
CONCLUSIONS: Megacapillaries were independently associated with greater WMH burden, which may help characterize systemic microangiopathic phenotypes relevant to cSVD. Longitudinal studies are needed to determine whether peripheral microvascular abnormalities track with WMH progression.
PMID:41962753 | DOI:10.1016/j.jstrokecerebrovasdis.2026.108633