Trends Genet. 2026 Sep 25:S0168-9525(26)00223-4. doi: 10.1016/j.tig.2026.09.003. Online ahead of print.
ABSTRACT
Exome sequencing of more than 1 million people uncovered dozens of genes linked to the biomarker of the body's energy state (Hindy et al.). Rare loss-of-function variants in FNIP1, a suppressor of mitochondrial energy expenditure, were associated with lower cardiometabolic disease risk, nominating selective FNIP1 inhibition as a therapeutic strategy.
PMID:42791079 | DOI:10.1016/j.tig.2026.09.003