NPJ Cardiovasc Health. 2026 May 4;3(1):24. doi: 10.1038/s44325-026-00118-5.
ABSTRACT
The association of pulse pressure (PP) with the severity and cardiovascular (CV) outcomes in stable coronary artery disease populations with normal ejection fraction are sparse. We enrolled 7,027 patients and follow-up 36.4 months, a total of 289 events occurred. Both systolic blood pressure (SBP) and PP were significantly increased by Gensini Score quartiles. Meanwhile, the percentage of 3-diseased vessels was increasing by PP quartiles (p < 0.001). On univariate analysis, both PP and SBP were associated with CV death, stroke, and combined outcome (p < 0.05, all). However, after adjusting for potential confounders, PP remains significantly associated with stroke (HR 95%CI 1.019[1.005-1.033]) and combined outcome (HR 95%CI 1.014[1.005-1.023]) while SBP was only associated with stroke (HR 95%CI 1.014[1.003-1.026]). On multivariate analysis, the highest PP quartile consistently associated with stroke and combined outcome (p < 0.05, all). This prospective cohort study suggesting that PP may be a pivotal predictor for CV risk.
PMID:42082683 | DOI:10.1038/s44325-026-00118-5