JACC Case Rep. 2026 Sep 19:110358. doi: 10.1016/j.jaccas.2026.110358. Online ahead of print.
ABSTRACT
BACKGROUND: Renal denervation (RDN) is a treatment option for resistant hypertension.
CASE SUMMARY: We present a 64-year-old woman with medication intolerance secondary to mast cell activation syndrome who presented with uncontrolled hypertension and underwent bilateral RDN. Her systolic and diastolic recordings measured using Dinamap device (GE Healthcare), decreased from 151 ± 7.6 and 75 ± 4.1 mm Hg to 126 ± 4.5 and 66 ± 2.8 mm Hg, respectively, at 3 months after her procedure (both P < 0.05).
DISCUSSION: We show that RDN can be used in patients with severe medication intolerance due to an autoimmune condition. We also highlight the utility of using office-automated testing, which allowed us to likely obtain more accurate multiple blood pressure readings over 15 minutes.
TAKE-HOME MESSAGE: This report highlights RDN's efficacy in a patient unable to tolerate pharmacological antihypertensive therapy and highlights the clinical utility of using automated blood pressure readings.
PMID:42763807 | DOI:10.1016/j.jaccas.2026.110358