Musculoskeletal Care. 2026 Sep;24(3):e70235. doi: 10.1002/msc.70235.
ABSTRACT
INTRODUCTION: Metabolic syndrome is a well-established cluster of cardiovascular risk factors with increasing relevance to musculoskeletal pain, function, and rehabilitation. Beyond its recognised effects on cardiovascular health, its systemic biological consequences may influence pain mechanisms, tissue health, recovery, and rehabilitation outcomes. Understanding these effects may enhance clinicians' assessment, clinical reasoning, and management of individuals presenting with musculoskeletal disorders.
METHOD: This narrative conceptual paper explores the potential biological mechanisms through which metabolic syndrome may influence musculoskeletal pain and rehabilitation. It proposes a clinically relevant framework to support the integration of metabolic health into musculoskeletal assessment and clinical reasoning, illustrated through a structured clinical vignette.
DISCUSSION: Musculoskeletal clinicians are increasingly managing individuals with complex, multimorbid presentations. Consideration of metabolic syndrome provides an additional dimension to clinical reasoning by recognising how systemic metabolic dysfunction may contribute to pain persistence, impaired tissue healing, reduced physical function, and variable responses to rehabilitation. Incorporating these factors into assessment and treatment planning may facilitate more individualised, person-centred rehabilitation strategies and optimise clinical outcomes.
CONCLUSION: Metabolic syndrome should be considered within the wider context of the biopsychosocial model and the social determinants of health, recognising their influence on health inequalities, disease burden, and rehabilitation outcomes. Integrating metabolic health into person-centred musculoskeletal practice may enhance clinical decision-making, support more targeted rehabilitation, and ultimately improve patient outcomes.
PMID:42401535 | DOI:10.1002/msc.70235