Clin Lab. 2026 Jun 1;72(3). doi: 10.7754/Clin.Lab.2025.250580.
ABSTRACT
BACKGROUND: Spontaneous intracerebral hemorrhage (ICH) presents a substantial public health challenge due to its high mortality rates. Although the platelet-to-white blood cell ratio (PWR) has been identified as an independent prognostic factor in various diseases, its association with ICH outcome remains unclear. This study aimed to investigate the relationship between PWR and the thirty-day mortality rate in patients with spontaneous supra-tentorial ICH.
METHODS: A retrospective analysis of 296 adult patients was conducted, collecting data on demographics, Glasgow Coma Score (GCS), underlying conditions, and laboratory results. PWR was calculated as the absolute value of the platelet-to-white blood cell ratio. The primary outcome was the thirty-day mortality during hospitalization. Multivariable logistic regression analysis was performed to identify independent predictors of thirty-day mortality.
RESULTS: The study revealed a significant inverse association between PWR and thirty-day mortality (odds ratio: 0.88, 95% CI: 0.79 - 0.98, p = 0.02). A 12% increase in mortality risk was observed for every unit decrease in PWR. Kaplan-Meier survival curves demonstrated a significantly lower survival rate within 30 days for patients with PWR < 15.0 (log-rank test: p < 0.01). Admission GCS and chronic kidney disease were also identified as independent predictors of thirty-day mortality (p = 0.04 and p < 0.01, respectively).
CONCLUSIONS: PWR is a significant predictor of thirty-day mortality in patients with spontaneous supratentorial ICH. Lower PWR values correspond to a higher mortality risk, highlighting the potential utility of PWR as a prognostic indicator for ICH patients.
PMID:41945738 | DOI:10.7754/Clin.Lab.2025.250580