Biomater Transl. 2025 Sep 11;7(2):275-298. doi: 10.12336/bmt.25.00029. eCollection 2026.
ABSTRACT
Biomaterials are engineered substances designed to interact with biological systems for therapeutic or diagnostic purposes. Their inherent properties-including biocompatibility, biodegradability, and structural versatility-have driven major advancements in drug delivery technologies. The global biomaterials market size was estimated at USD 178.0 billion in 2023 and is projected to grow at a compound annual growth rate of 15.6% from 2024 to 2030. The growing incidence of musculoskeletal and chronic skeletal disorders is expected to drive demand for biomaterial-based implants, thereby contributing to market expansion. This review critically examines biomaterials, focusing on their classification into biobased, biodegradable, and biocompatible categories and analyzes their physicochemical properties and functional benefits. It highlights their applications in oncology, cardiovascular therapy, neurodegenerative diseases, and vaccination. Key challenges-including immunogenicity, cytotoxicity, and manufacturing complexities-are discussed, emphasizing the need for rigorous evaluation and adaptive regulatory frameworks. The review also explores recent advances in smart biomaterials for precision drug delivery, underscoring their potential to revolutionize personalized medicine through targeted, efficient, and patient-specific therapies.
PMID:42760964 | PMC:PMC13585499 | DOI:10.12336/bmt.25.00029