JACC Basic Transl Sci. 2026 Jul 10;11(8):101632. doi: 10.1016/j.jacbts.2026.101632. Online ahead of print.
ABSTRACT
Metabolic dysfunction-associated steatotic liver disease is associated with vitamin D deficiency, and platelets exhibit hyperactivity. Zhang et al provide novel insights into the mechanisms underlying platelet hyperreactivity and thrombotic risk in patients with metabolic dysfunction-associated steatotic liver disease, demonstrating that calcitriol activates the vitamin D receptor in megakaryocytes and platelets, leading to the downregulation of P2Y12 expression and the modulation of the cyclic adenosine monophosphate/protein kinase A and mitogen-activated protein kinase signaling pathways, thereby attenuating platelet activation.
PMID:42430854 | DOI:10.1016/j.jacbts.2026.101632