Adv Exp Med Biol. 2026;1498:225-229. doi: 10.1007/978-3-032-10389-5_27.
ABSTRACT
The objective was to quantify the effect of endovascular therapy (EVT) results of large-vessel occlusion (LVO) on brain tissue hydration, assessed by net water uptake (NWU).
MATERIALS AND METHODS: Ninety-three patients with EVT of acute ischemic stroke (AIS) due to acute LVO (men-44, women-49, median age 68.7) were included in this retrospective, non-randomized, single-center study. EVT was performed under general anesthesia with approved devices, including a stent retriever and aspiration catheters. Net water uptake (NWU) in ischemic zones was evaluated using non-contrasted computed tomography (CT). NWU was calculated using the well-known formula in the symmetrical zone of the brain, in admission and follow-up non-contrasted CT scans, 24 h after EVT.
RESULTS: Fifty-seven patients had successful arterial recanalization (Thrombolysis in Cerebral Infarction scale [TICI] 2b-3), while 36 patients had persistent or recurrent acute LVO (TICI 0-2a). The NWU median at admission was 3.4% in patients with successful EVT and 5.1% in patients with unsuccessful EVT (p < 0.05). The follow-up NWU median was 7.2% after successful EVT and 12.8% in patients with persistent/recurrent acute LVO (p < 0.001).
CONCLUSION: Successful arterial recanalization at AIS due to LVO (TICI 2b -3) led to a significant reduction in brain edema progression in cerebral ischemic foci.
PMID:41577922 | DOI:10.1007/978-3-032-10389-5_27