J Vis Exp. 2025 Dec 23;(226). doi: 10.3791/69356.
ABSTRACT
Panvascular disease is a type of multi-systemic vascular disorder, primarily characterized by atherosclerotic vascular lesions as a common pathological feature, encompassing cardiovascular diseases, cerebrovascular diseases, and peripheral vascular diseases, among others. The crucial involvement of non-coding RNA (ncRNA), particularly microRNA, long non-coding RNA, and circular RNA, in different types of panvascular disease has been thoroughly studied. Recent studies have indicated that these regulatory RNA molecules are involved in the mechanisms underlying panvascular diseases by modulating pathophysiological processes such as vascular endothelial function, inflammatory response, apoptosis, and proliferation. However, there is currently no systematic review on the research progress of ncRNA in panvascular disease. Therefore, in order to provide a comprehensive and systematic discussion of the importance of ncRNA in panvascular disease. This study provides a comprehensive synthesis of recent ncRNA research in panvascular disease from basic, clinical, and translational perspectives, aiming to elucidate its specific biological roles and pathogenic mechanisms. This review is conducive to the better development of targeted treatments targeting ncRNA in panvascular disease.
PMID:41525228 | DOI:10.3791/69356