Clin Lab. 2026 Apr 1;72(4). doi: 10.7754/Clin.Lab.2025.250578.
ABSTRACT
BACKGROUND: Test results and outliers are of great significance to disease diagnosis, especially in some inconspicuous hematological diseases. This report presents a case of Waldenström's macroglobulinemia diagnosed following abnormal biochemical test results.
METHODS: The laboratory of our hospital conducted a review of the patient's specimen due to a negative creatinine value, despite normal reagents, quality controls, and instrument status. It was found that the specimen was non-lipemic, but it became turbid immediately after the addition of distilled water. Subsequent tests were carried out based on multiple abnormal findings. Biochemical tests were additionally performed, including blood immunoglobulin and serum protein electrophoresis. The presence of serum M protein was detected.
RESULTS: The diagnosis of Waldenström's macroglobulinemia was confirmed through consultation between the clinical physician and the laboratory physician.
CONCLUSIONS: In clinical practice, it is not uncommon for test results to be abnormal. The role of laboratory workers is to quickly and accurately identify the causes of these abnormalities, so that clinicians can promptly diagnose patients and proceed with subsequent treatments.
PMID:41979633 | DOI:10.7754/Clin.Lab.2025.250578