Tunis Med. 2025 Dec 27;103(10):1444-1453. doi: 10.62438/tunismed.v103i10.5892.
ABSTRACT
BACKGROUND: The rising prevalence of chronic diseases, including cancer, metabolic disorders, neurodegenerative, and cardiovascular conditions, presents a growing challenge to modern medicine and public health.
AIM: This article investigates the potential of polyphenols as modulators of epigenetic mechanisms in the context of chronic disease.
METHODS: A comprehensive review of scientific literature was conducted, with emphasis on key epigenetic processes such as DNA methylation, histone modifications, and microRNA regulation.
RESULTS: Polyphenols like resveratrol, curcumin, quercetin, and catechins exert protective actions by modulating gene expression, counteracting harmful epigenetic changes, and supporting cellular health.
CONCLUSION: Advancing our understanding of how polyphenols influence epigenetic pathways may lead to innovative therapeutic strategies combining conventional and personalized approaches.
PMID:41879695 | DOI:10.62438/tunismed.v103i10.5892