Zhonghua Xue Ye Xue Za Zhi. 2026 Jun 14;47(6):582-586. doi: 10.3760/cma.j.cn121090-20260115-00028.
ABSTRACT
The clinical data of 57 patients with multiple myeloma (MM) who underwent autologous hematopoietic stem cell transplantation (auto-HSCT) at the Second Affiliated Hospital of Anhui Medical University from July 2020 to August 2025 were retrospectively analyzed. Peripheral blood lymphocyte subsets before transplantation were detected by flow cytometry. Multivariate analysis showed that a higher infused CD34(+)cell count (HR=0.739, P=0.043) and a higher proportion of regulatory T cells before transplantation (HR=0.728, P=0.009) were independent favorable prognostic factors for rapid neutrophil engraftment. A higher infused CD34(+)cell count (HR=0.849, P=0.042) and a higher pre-transplant NK cell count (HR=0.991, P=0.038) were independent favorable prognostic factors for rapid megakaryocyte engraftment. With a median follow-up of 9.9 (0.5-55.0) months, a higher ratio of CD4(+) T-cell percentage to CD8(+) T-cell percentage before transplantation was an independent risk factor for progression-free survival (HR=1.627, 95% CI: 1.159-2.284, P=0.005). This study demonstrated that lymphocyte subsets before auto-HSCT are associated with the speed of hematopoietic reconstitution and the risk of relapse in MM patients.
PMID:42706160 | DOI:10.3760/cma.j.cn121090-20260115-00028