Anaesthesiol Intensive Ther. 2025 Nov 27;57(1):340-355. doi: 10.5114/ait/210612.
ABSTRACT
Intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) are now recognized as important but often underdiagnosed contributors to cardiovascular instability in critically ill patients. Recent studies have clarified the mechanisms by which elevated intra-abdominal pressure (IAP) reduces venous return, raises intrathoracic pressure, and impairs both preload and contractility while increasing afterload. These pathophysiological changes can compromise organ perfusion even at modest IAP elevations, and the interplay between cardiovascular, renal, and hepatic dysfunction has led to the concept of the cardio-abdomino-renal syndrome. Advances in monitoring have shifted practice away from static pressure indices such as central venous and pulmonary artery occlusion pressures. Emerging evidence supports the use of abdominal perfusion pressure, mean perfusion pressure, and volumetric indices obtained by transpulmonary thermodilution, alongside echocardiography and ultrasound-based venous congestion assessment. These tools enable individualized resuscitation strategies, balancing fluid therapy with the risks of exacerbating IAH. The purpose of this review is to synthesize recent evidence on the cardiovascular consequences of IAH and ACS, highlight evolving monitoring techniques, and outline current approaches to management. By integrating updated concepts into clinical practice, early recognition and targeted interventions may mitigate multi-organ dysfunction and improve patient outcomes.
PMID:41362929 | DOI:10.5114/ait/210612