BMJ Case Rep. 2026 Aug 3;19(8):e269533. doi: 10.1136/bcr-2025-269533.
ABSTRACT
Heyde syndrome (HS) is defined as the association between severe aortic valve stenosis and angiodysplasias (AD)-related bleeding. It is thought to occur as a consequence of an acquired type 2A von Willebrand disease, promoted by the high shear stress generated by the stenotic valve. It appears to be an underdiagnosed condition. We report a case of HS in which gastrointestinal (GI) bleeding was identified in duodenal and jejunal AD. Bleeding was successfully treated with argon plasma coagulation. Additionally, the patient underwent a transcatheter aortic valve implantation, after which he experienced improvement in heart failure symptoms and no further episodes of GI bleeding.
PMID:42547253 | DOI:10.1136/bcr-2025-269533