J Clin Hypertens (Greenwich). 2026 Jan;28(1):e70209. doi: 10.1111/jch.70209.
ABSTRACT
The weight-adjusted waist index (WWI) is a novel indicator that could estimate body fat and muscle mass. This study aimed to investigate the relationship between WWI and hypertension plus hyperuricemia (HTN-HUA). The data were drawn from the China Health and Retirement Longitudinal Study. Logistic regression analyses were used to explore the association between WWI with HTN-HUA, hypertension (HTN) alone, and hyperuricemia (HUA) alone. Restricted cubic spline (RCS) analyses were employed to examine potential nonlinear associations. Receiver operating characteristic (ROC) curves were utilized to assess the predictive ability of WWI. A total of 9801 participants were included, among whom 756 (8%) were diagnosed with HTN-HUA, 4381 (45%) with HTN alone, and 1236 (13%) with HUA alone. WWI was significantly associated with HTN-HUA, HTN alone, and HUA alone after adjusting for potential confounders. Compared to the lowest quartiles of WWI, the odds ratios of the highest quartiles were 3.04 (95% confidence interval [CI]: 2.35-3.94) for HTN-HUA, 1.53 (95% CI: 1.34-1.74) for HTN alone, and 1.93 (95% CI: 1.42-2.61) for HUA alone. RCS analyses demonstrated a nonlinear association between WWI with HTN-HUA. The fully adjusted model, which included WWI, exhibited a moderate predictive ability for HTN-HUA (area under the curve: 0.753, 95% CI 0.736-0.771). The association between WWI and HTN-HUA was more prominent among individuals between 45 and 59 years and those without diabetes. In this cross-sectional analysis, higher WWI was significantly associated with the prevalence of the HTN-HUA phenotype, warranting confirmation in prospective studies with clinical endpoints.
PMID:41587211 | DOI:10.1111/jch.70209