Medicine (Baltimore). 2026 Jun 26;105(26):e49490. doi: 10.1097/MD.0000000000049490.
ABSTRACT
The relationship between the mean platelet volume-to-lymphocyte ratio (MPVLR), a composite indicator of the body's inflammatory response and immune function, and the prognosis of cancer patients is unclear. A total of adult cancer patients with complete information between 1999 and 2018 were included in this study. The Cox proportional hazards model was used to investigate the association between MPVLR levels and all-cause and cardiovascular disease (CVD) mortality in adult cancer patients. The probability of all-cause and CVD mortality in cancer patients with different MPVLR levels was compared by plotting Kaplan-Meier survival curves. Restricted cubic spline analysis, threshold effect analysis, and subgroup analysis were also used. This study ultimately included a total of 3997 adult cancer patients, with a median age of 69 years. During a median follow-up period of 7.08 years, a total of 1379 (34.50%) all-cause deaths and 299 (7.48%) deaths from CVD occurred. According to the Cox proportional hazards model analysis, MPVLR was associated with all-cause mortality rate (hazard ratio [95% confidence interval]: 1.13 [1.11-1.16], P < .001) and a CVD mortality rate (hazard ratio [95% confidence interval]: 1.16 [1.11-1.20], P < .001), which were significantly associated with an increased risk of mortality. Kaplan-Meier survival curve analyses showed that the prognosis of the high-level MPVLR group was significantly worse than that of the low-level group. This association persisted in subgroup analyses based on age, sex, race, marital status, education level, ratio of family income to poverty, body mass index, smoking status, drinking status, hypertension, and diabetes. Restricted cubic spline analysis models showed a nonlinear association between MPVLR and all-cause or CVD mortality in adult cancer patients. Higher MPVLR levels were significantly associated with an increased risk of all-cause and CVD mortality in adult cancer patients. There was a nonlinear relationship between MPVLR and all-cause or CVD mortality in adult cancer patients.
PMID:42363507 | DOI:10.1097/MD.0000000000049490