Sci Rep. 2026 Jan 23. doi: 10.1038/s41598-026-35737-6. Online ahead of print.
ABSTRACT
Atherosclerotic cardiovascular disease (ASCVD) is a major cause of mortality worldwide. This study aims to investigate the relationship between the 10-year ASCVD risk score and mental disorders.This study analyzed data from 1154 participants aged 25 to 70 enrolled in the Shiraz Heart Study cohort between 2016 and 2019. The ten-year ASCVD risk score was estimated using the ASCVD risk score estimator recommended by the American College of Cardiology and American Heart Association guidelines. Mental health was evaluated using a 28-item general health questionnaire concurrently with the ASCVD risk calculation. A multiple logistic regression model was employed for multivariate analysis. The mean age of participants was 44.25 ± 8.88 years, and most were men (n = 621, 53.8%). A multiple logistic regression model demonstrated that having ASCVD is associated with increased odds of somatic symptoms (OR 1.138, 95% CI 1.069-1.212), anxiety and insomnia (OR 1.113, 95% CI 1.043-1.188), severe depression (OR 1.173, 95% CI 1.084-1.269), and total general health scores (OR 1.053, CI 1.027-1.079). Another multiple logistic regression model showed that among participants without ASCVD, 10-year ASCVD risk score ≥ 5% is associated with increased odds of somatic symptoms (OR 1.126 95%CI 1.035-1.224), anxiety and insomnia (OR 1.117, 95% CI 1.031-1.211), social dysfunction (OR 1.121, 95% CI 1.034-1.215), severe depression (OR 1.195, 95% CI 1.078-1.324), and total general health scores (OR 1.068, CI 1.035-1.102). ASCVD and a 10-year ASCVD risk score ≥ 5 are associated with the development of mental disorders.
PMID:41577951 | DOI:10.1038/s41598-026-35737-6