AIDS. 2025 Nov 21. doi: 10.1097/QAD.0000000000004414. Online ahead of print.
ABSTRACT
OBJECTIVE: This study aimed to assess the burden, severity, and pattern of Coronary artery disease (CAD) in people with HIV (PWH), as well as its relationship with metabolic syndrome, inflammation, and endothelial dysfunction.
DESIGN: Cross-sectional study.
METHODS: A comparative cross-sectional study was conducted on 72 PWH and 72 matched people without HIV at Aminu Kano Teaching Hospital (AKTH). Data collection included demographics, metabolic parameters, viral load, brachial artery flow-mediated dilation (BAFMD) assessed via ultrasound, and coronary artery calcification (CAC) scores obtained using electrocardiogram (ECG)-gated computed tomography. CAD predictors were analysed using t-tests, linear regression, and Chi-squared/Fisher's exact tests (p ≤ 0.05).
RESULTS: Among 144 participants (72 PWH, 72 controls), PWH had higher CAD prevalence (31.9% vs. 4.2%, p < 0.001) and mean CAC scores (23.2 vs. 2.7, p < 0.001). CAD was significantly associated with longer ART duration (p = 0.04), higher BMI (p = 0.005), and reduced BAFMD (p = 0.020). In controls, hsCRP predicted CAD (p = 0.004).
CONCLUSION: PWH in northern Nigeria have a higher burden of CAD compared to HIV negative controls, with greater CAC and endothelial dysfunction, independent of viral load status. These findings highlight the need for routine cardiovascular screening and CVD prevention integration into HIV care.
PMID:41284327 | DOI:10.1097/QAD.0000000000004414