BMJ Open. 2026 Jun 3;16(6):e117719. doi: 10.1136/bmjopen-2026-117719.
ABSTRACT
OBJECTIVES: To examine whether the use of a venous access-site closure device is associated with the occurrence of postoperative nausea and vomiting (PONV) after atrial fibrillation (AF) ablation under propofol sedation.
DESIGN: Observational study.
SETTING: A single-centre retrospective observational study in Okayama, Japan.
PARTICIPANTS: We retrospectively analysed consecutive patients who underwent AF ablation under deep propofol sedation with adaptive servo-ventilation. A total of 686 patients were included. Patients were managed using a standardised sedation protocol with or without low-dose pentazocine. Patients treated with conventional manual compression for haemostasis (n=383) were compared with those treated using a venous access-site closure device (n=303).
INTERVENTIONS: Postprocedural bed rest duration and the incidence and timing of PONV were compared between groups. Associations between closure device use and PONV were evaluated using logistic regression analysis.
PRIMARY OUTCOME MEASURE: The primary outcome was the occurrence of PONV following AF ablation.
RESULTS: All procedures were completed under propofol sedation without conversion to general anaesthesia. The duration of postprocedural bed rest was shorter in the device group than in the conventional-compression group (mean difference -14.7 hours, 95% CI -15.2 to -14.0).PONV occurred in 6/303 patients (2.0%) in the device group and 20/383 patients (5.2%) in the conventional-compression group, corresponding to a relative risk of 0.38 (95% CI 0.15 to 0.93), an OR 0.25 (95% CI 0.10 to 0.62) and a risk difference of -3.2% (95% CI -6.0% to -0.5%).In multivariable analysis, use of a venous closure device was associated with a lower likelihood of PONV.
CONCLUSIONS: In this single-centre observational study, use of a venous access-site closure device was associated with a lower occurrence of PONV after AF ablation under propofol sedation. These findings suggest that postprocedural management strategies enabling earlier mobilisation may be associated with improved patient comfort; however, causal inference is limited by the observational design.
PMID:42236090 | DOI:10.1136/bmjopen-2026-117719