Diabetes Res Clin Pract. 2026 Jan 21:113112. doi: 10.1016/j.diabres.2026.113112. Online ahead of print.
ABSTRACT
BACKGROUND: The associations between blood count-derived inflammatory indices and mortality risk in individuals with diabetes and prediabetes have gained attention, but systematic studies are lacking.
METHODS: Data from the National Health and Nutrition Examination Survey (NHANES) were analyzed to investigate various inflammatory indices (such as the SII and NLR) in relation to all-cause mortality, cardiovascular disease (CVD) mortality, and diabetes-specific mortality via the Cox proportional hazards model.
RESULTS: A total of 12,119 participants were included, with an average age of 60 years and approximately 52 % being male. During the follow-up, the overall mortality rate was 25.7 %. All nine inflammatory indices were significantly associated with all-cause mortality and CVD mortality (P < 0.01), and eight indices were correlated with diabetes-specific mortality. Eight indices exhibited significant nonlinear relationships with all-cause mortality, with the exception of the NPR, whereas theSIRI, PLR, NPR, and MPRshowed significant nonlinear associations with CVD mortality.
CONCLUSION: Inflammatory indices such as the SII, SIRI, and NLR are significantly associated with all-cause and CVD mortality among U.S. adults with diabetes and prediabetes, demonstrating index-specific association patterns and threshold characteristics.
PMID:41577297 | DOI:10.1016/j.diabres.2026.113112