iScience. 2026 Jul 24;29(8):116904. doi: 10.1016/j.isci.2026.116904. eCollection 2026 Aug 21.
ABSTRACT
Echocardiographic interpretation underlies a large share of cardiovascular diagnoses, yet specialist expertise remains unevenly distributed, and quantitative measurements show inter-observer variability of 15-17% that contributes to disagreement in borderline cases. We developed DeepCard, a multi-task deep learning system that produces standardized, reproducible interpretation of pre-measured echocardiographic parameters by jointly analyzing 39 quantitative measurements across 17 diagnostic tasks spanning valvular disease, ventricular dysfunction, and structural abnormalities. Trained on 400 patients, DeepCard reached 91% specificity for valvular assessment and 82% accuracy for ventricular evaluation, and reduced inter-observer interpretive variability for pre-measured parameters to 13.4%. On an independent external cohort of 102 patients from a separate institution, performance decreased by only 2.6%, indicating consistent generalization. By providing standardized interpretation of quantitative measurements, DeepCard may help clinicians achieve more consistent and reproducible cardiac assessment, particularly in settings where specialist availability is limited.
PMID:42564461 | PMC:PMC13444440 | DOI:10.1016/j.isci.2026.116904