Curr Med Res Opin. 2026 Oct 14:1-11. doi: 10.1080/03007995.2026.2743357. Online ahead of print.
ABSTRACT
BACKGROUND: The Aggregate Index of Systemic Inflammation (AISI) is a potential cardiovascular risk indicator. Its association with contemporaneous myocardial injury in coronary heart disease (CHD) patients remains unclear.
OBJECTIVE: To explore the association between AISI and elevated myocardial injury markers and evaluate its discriminatory performance.
METHODS: In this single-centre retrospective study of consecutive CHD patients, AISI was calculated at admission. The patients were assessed at admission and before coronary angiography. Elevated cTnT was defined as >0.014 ng/mL and elevated CK-MB as >24 U/L. Logistic regression, subgroup analyses, ROC curves, and restricted cubic splines (RCS) were used.
RESULTS: Significant differences across AISI tertiles were observed in adverse profiles. In multivariable-adjusted models, each unit increase in continuous AISI was associated with higher odds of elevated cTnT (OR = 1.30, 95% CI: 1.10, 1.55, p = 0.003) and elevated CK-MB (OR = 1.09, 95% CI: 1.02,1.17, p = 0.01). Compared with T1, T3 showed a significantly increased risk of elevated cTnT (OR = 3.14, 95% CI: 1.93,5.12, p < 0.01). Subgroup analyses revealed that AISI was more strongly associated with cTnT elevation in patients aged <70 years and in men, while the association with CK-MB was more evident in women and those aged ≥70 years. ROC analysis demonstrated moderate predictive value for cTnT (AUC = 0.72, 95% CI: 0.69, 0.75) and limited value for CK-MB (AUC = 0.65). RCS identified a nonlinear relationship with cTnT (P for nonlinearity = 0.0016), with an inflection point at 212.41.
CONCLUSION: Elevated AISI is independently associated with myocardial injury biomarkers in CHD patients, particularly for cTnT elevation, with a nonlinear threshold effect near 212.4. This association varies by age and sex, suggesting that AISI may serve as a simple, cost-effective adjunctive marker for identifying CHD patients at risk of myocardial injury.
PMID:42870772 | DOI:10.1080/03007995.2026.2743357